CACTUS: INTEGRATING CLONAL ARCHITECTURE WITH GENOMIC CLUSTERING AND TRANSCRIPTOME PROFILING OF SINGLE TUMOR CELLS

CACTUS: integrating clonal architecture with genomic clustering and transcriptome profiling of single tumor cells

Abstract Background Drawing genotype-to-phenotype maps in tumors is of paramount importance for understanding tumor heterogeneity.Assignment of single cells to their tumor clones of origin can be approached by matching the genotypes of the clones to the mutations found in RNA sequencing of the cells.The confidence of the cell-to-clone mapping can b

read more

Understanding the notion of function and articulation of semiotic records that represent between students entering a program Engineering

This study aims to assess the understanding of the notion of function and the ability to articulate different semiotic registers for representation by new students in the university in Colombia.Immediate context is taken as the Faculty of Engineering at a public university.Epistemologically the study is based on symbolic interaction by analyzing th

read more


A Literature Synthesis of Actions to Tackle Illegal Parrot Trade

The order Psittaciformes is one of the most prevalent groups in the illegal wildlife trade.Efforts to understand this threat have focused on describing the elements of the trade itself: actors, extraction rates, and routes.However, the development of policy-oriented interventions also requires an understanding of how research aims and classic carle

read more

Study on optimal design of mistuned bladed disk

Although, in designing blades, it is assumed that all blades on a disk are identical (tuned system), the vibration characteristics of the blade is slightly different due to the 30x24x24 wall cabinet manufacturing tolerance, the deviation of the material property, and so on (mistuned system).As a result, in the forced response of an actual bladed di

read more